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Index > Protein center > TFAP2B(Gene name) > Human
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  • TFAP2B (Gene name),
  • Transcription factor AP-2-beta (Protein name ),  AP2B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    TFAP2B;
    Protein name:
    Transcription factor AP-2-beta(AP2-beta);
    Alternative:
    Activating enhancer-binding protein 2-beta;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity.
    Function:
    Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    460
    Sequence:
    50:
    MHSPPRDQAA | IMLWKLVENV | KYEDIYEDRH | DGVPSHSSRL | SQLGSVSQGP | 
    100:
    YSSAPPLSHT | PSSDFQPPYF | PPPYQPLPYH | QSQDPYSHVN | DPYSLNPLHQ | 
    150:
    PQQHPWGQRQ | RQEVGSEAGS | LLPQPRAALP | QLSGLDPRRD | YHSVRRPDVL | 
    200:
    LHSAHHGLDA | GMGDSLSLHG | LGHPGMEDVQ | SVEDANNSGM | NLLDQSVIKK | 
    250:
    VPVPPKSVTS | LMMNKDGFLG | GMSVNTGEVF | CSVPGRLSLL | SSTSKYKVTV | 
    300:
    GEVQRRLSPP | ECLNASLLGG | VLRRAKSKNG | GRSLRERLEK | IGLNLPAGRR | 
    350:
    KAANVTLLTS | LVEGEAVHLA | RDFGYICETE | FPAKAVSEYL | NRQHTDPSDL | 
    400:
    HSRKNMLLAT | KQLCKEFTDL | LAQDRTPIGN | SRPSPILEPG | IQSCLTHFSL | 
    450:
    ITHGFGAPAI | CAALTALQNY | LTEALKGMDK | MFLNNTTTNR | HTSGEGPGSK | 
    460:
    TGDKEEKHRK | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    KEGG:
    UniGene:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human AP2-beta
    Cat.:
    E0510h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human AP2-beta
    Cat.:
    E0510d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human AP2-beta
    Cat.:
    E0510m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AP2-beta
    Cat.:
    U0510h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human AP2-beta
    Cat.:
    U0510d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AP2-beta
    Cat.:
    U0510m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human AP2-beta
    Polyclonal Antibody for Human AP2-beta
    Cat.:
    P0510Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AP2-beta
    Cat.:
    P0510Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human AP2-beta
    Monoclonal Antibody for Human AP2-beta
    Monoclonal Antibody for Human AP2-beta
    Protein for Human AP2-beta
    Protein for Human AP2-beta
    Protein for Human AP2-beta

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta."
      Moser M. , Buettner R.
      Genes Dev.11:1938-1948(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    2. 2.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Skin.
    4. 4.
      "Characterisation of the human AP-2beta and AP-2gamma genes."
      Hasleton M.D. , Skinner A. , Hurst H.C.
      Submitted (2000-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27
    5. 5.
      "Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors."
      Williamson J.A. , Bosher J.M. , Skinner A. , Sheer D. , Williams T. , Hurst H.C.
      Genomics35:262-264(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-460 (ISOFORM 1)
      tissue: Mammary tumor.
    6. 6.
      "Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator."
      Bamforth S.D. , Braganca J. , Eloranta J.J. , Murdoch J.N. , Marques F.I. , Kranc K.R. , Farza H. , Henderson D.J. , Hurst H.C. , Bhattacharya S.
      Nat. Genet.29:469-474(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CITED2
    7. 7.
      "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2."
      Braganca J. , Swingler T. , Marques F.I.R. , Jones T. , Eloranta J.J. , Hurst H.C. , Shioda T. , Bhattacharya S.
      J. Biol. Chem.277:8559-8565(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CITED4
    8. 8.
      "Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo."
      Eloranta J.J. , Hurst H.C.
      J. Biol. Chem.277:30798-30804(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBE2I;SUMOYLATION AT LYS-21
    9. 9.
      "Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2."
      Braganca J. , Eloranta J.J. , Bamforth S.D. , Ibbitt J.C. , Hurst H.C. , Bhattacharya S.
      J. Biol. Chem.278:16021-16029(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CITED2
    10. 10.
      "The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation."
      Ding X. , Luo C. , Zhou J. , Zhong Y. , Hu X. , Zhou F. , Ren K. , Gan L. , He A. , Zhu J. , Gao X. , Zhang J.
      J. Cell. Biochem.106:285-295(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KCTD1
    11. 11.
      "Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus."
      Satoda M. , Zhao F. , Diaz G.A. , Burn J. , Goodship J. , Davidson H.R. , Pierpont M.E.M. , Gelb B.D.
      Nat. Genet.25:42-46(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CHAR ASP-275 AND CYS-300
    12. 12.
      "Novel TFAP2B mutations that cause Char syndrome provide a genotype-phenotype correlation."
      Zhao F. , Weismann C.G. , Satoda M. , Pierpont M.E.M. , Sweeney E. , Thompson E.M. , Gelb B.D.
      Am. J. Hum. Genet.69:695-703(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CHAR ARG-73; CYS-236; SER-236 AND GLN-285
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